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排序方式: 共有1930条查询结果,搜索用时 62 毫秒
51.
Irene Fragiadaki Stavros Papadakis Georgia Sevastaki Katerina Sfyridaki Irene Mavroudi George N. Goulielmos Peggy Kanellou Anette Mörtberg Petter Höglund Katerina Gemenetzi Kostas Stamatopoulos Anastasia Chatzidimitriou Jan Palmblad Helen A. Papadaki 《American journal of hematology》2020,95(7):E163-E166
52.
Yulia Lin Everad Tilokee Sophie Charg Asim Alam Christine Cserti‐Gazdewich Wendy Lau Christie Lee Lani Lieberman Paula Nixon Wendy Owens Katerina Pavenski Jacob Pendergrast Elianna Saidenberg Nadine Shehata Robert Skeate Qi‐Long Yi David Conrad Jill Dudebout Cyrus C. Hsia Michael Murphy Oksana Prokopchuk‐Gauk Akshay Shah Ziad Solh Jacqueline Trudeau Michelle P. Zeller Jeannie Callum 《Transfusion》2019,59(6):2141-2149
53.
Asimina Valsamaki Maria Xanthoudaki Katerina G Oikonomou Panagiotis J Vlachostergios Antonios Papadogoulas Periklis Katsiafylloudis Ioanna Voulgaridi Apostolia-Lemonia Skoura Apostolos Komnos Panagiotis Papamichalis 《World Journal of Clinical Cases》2023,11(3):514-527
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, broke out in December 2019 in Wuhan city of China and spread rapidly worldwide. Therefore, by March 2020, the World Health Organization declared the disease a global pandemic. Apart from the respiratory system, various other organs of the human body are also seriously affected by the virus. Liver injury in patients with a severe form of COVID-19 is estimated to be 14.8%-53.0%. Elevated levels of total bilirubin, aspartate aminotransferase and alanine aminotransferase and low levels of serum albumin and prealbumin are the main laboratory findings. Patients with pre-existing chronic liver disease and cirrhosis are much more prone to develop severe liver injury. This literature review presented the recent scientific findings regarding the pathophysiological mechanisms responsible for liver injury in critically ill patients with COVID-19, the various interactions between drugs used to treat the disease and the function of the liver and the specific tests providing the possibility of early diagnosis of severe liver injury in these patients. Moreover, it highlighted the burden that COVID-19 put on health systems worldwide and its effect on transplant programs and the care provided to critically ill patients in general and particularly to those with chronic liver disease. 相似文献
54.
Kotzampassi K Grosomanidis V Papakostas P Penna S Eleftheriadis E 《Obesity surgery》2012,22(6):896-903
Background
The BioEnterics Intragastric Balloon (BIB) has been considered an effective, less invasive method for weight loss, as it provides a permanent sensation of satiety. However, various non-randomized studies suggest BIB is a temporary anti-obesity treatment, which induces only a short-term weight loss. The purpose of this study was to present data of 500 obese who, after BIB-induced weight reduction, were followed up for up to 5?years.Methods
The BioEnterics BIB was used, and remained for 6?months. At 6, 12, and 24?months post-removal (and yearly thereafter), all subjects were contacted for follow-up.Results
From 500 patients enrolled, 26 were excluded (treatment protocol interruption); 474 thus remained, having initial body weight of 126.16?±?28.32?kg, BMI of 43.73?±?8.39?kg/m2, and excess weight (EW) of 61.35?±?25.41. At time of removal, 79 (17%) were excluded as having percent excessive weight loss (EWL) of <20%; the remaining 395 had weight loss of 23.91?±?9.08?kg (18.73%), BMI reduction of 8.34?±?3.14?kg/m2 (18.82%), and percent EWL of 42.34?±?19.07. At 6 and 12?months, 387 (98%) and 352 (89%) presented with weight loss of 24.14?±?8.93 and 16.31?±?7.41?kg, BMI reduction of 8.41?±?3.10 and 5.67?±?2.55?kg/m2, and percent EWL of 42.73?±?18.87 and 27.71?±?13.40, respectively. At 12 and 24?months, 187 (53%) and 96 (27%) of 352 continued to have percent EWL of >20. Finally, 195 of 474 who completed the 60-month follow-up presented weight loss of 7.26?±?5.41?kg, BMI reduction of 2.53?±?1.85?kg/m2, and percent EWL of 12.97?±?8.54. At this time, 46 (23%) retained the percent EWL at >20. In general, those who lost 80% of the total weight lost during the first 3 months of treatment succeeded in maintaining a percent EWL of >20 long term after BIB removal: more precisely, this cutoff point was achieved in 83% at the time of removal and in 53%, 27%, and 23% at 12-, 24-, and 60-month follow-up.Conclusion
BIB seems to be effective for significant weight loss and maintenance for a long period thereafter, under the absolute prerequisite of patient compliance and behavior change from the very early stages of treatment. 相似文献55.
Katerina A Christopoulos Sheri D Weiser Kimberly A Koester Janet J Myers Douglas AE White Beth Kaplan Stephen F Morin 《BMC public health》2012,12(1):3
Background
Despite high rates of patient satisfaction with emergency department (ED) HIV testing, acceptance varies widely. It is thought that patients who decline may be at higher risk for HIV infection, thus we sought to better understand patient acceptance and refusal of ED HIV testing. 相似文献56.
Megan A. Hayter MD Katerina Pavenski MD James Baker MD 《Journal canadien d'anesthésie》2012,59(12):1130-1145
Purpose
Massive transfusion has recently been given a dynamic definition, namely, the replacement of more than four red cell concentrates within an hour. The purpose of this continuing professional development module is to review the pathophysiology of hemorrhagic shock in the trauma patient and the current management strategies of the massively bleeding trauma patient.Principal findings
The massively bleeding trauma patient requires concurrent hemorrhage control and blood replacement therapy. Although there are many complications of massive transfusions, such as acid-base disturbances, electrolyte abnormalities, and hypothermia, perhaps the most difficult aspect to manage is acute trauma coagulopathy. Historically, coagulopathy was attributed to dilution of coagulation factors; however, recent accumulated evidence indicates that it is a multifactorial process associated with hypoperfusion, factor consumption, and hyperfibrinolysis. In an attempt to minimize acute trauma coagulopathy, massive transfusion protocols with equal ratios of red cell concentrates, frozen plasma, and platelets have been proposed. This type of hemostatic resuscitation, with near equal ratios of blood and blood products, has improved survival, but it is not without risk. In addition to the rapid and effective restoration of blood volume, the specific goal of transfusion management should be to maintain the patient??s oxygen carrying capacity, hemostasis, and biochemistry.Conclusion
The current literature does not permit firm conclusions to be drawn regarding optimal transfusion ratios. It remains appropriate, however, to devise a massive transfusion protocol at the institutional level that provides treating physicians with rapid delivery of a reasonable initial ratio of products. This would permit patient-centred management with an emphasis on surgical control of bleeding, maintenance of normothermia, avoidance of electrolyte abnormalities, acid-base balance, and the timely delivery of blood products.Objectives
After reading this module, the reader should be able to:- Enumerate the complications associated with massive transfusion in the trauma context;
- Understand how the coagulopathy present in the trauma patient differs from that seen in the elective setting;
- Identify the modifications suggested by the recent literature for the management of massive transfusion in the trauma setting;
- Appreciate the evidence for the institution of massive transfusion protocols.
57.
Akesson B Smyth JM Mandell DJ Doan T Donina K Hoven CW 《Social work in public health》2012,27(1-2):148-164
Despite the existing body of research examining the effects of imprisonment on incarcerated adults, as of yet, there is no solid empirical evidence for understanding the effects of parental involvement with the criminal justice system involvement (CJSI) on children and families. Accordingly, Columbia University-New York State's Child Psychiatric Epidemiology Group (CPEG), supported by a strong collaboration with The Bronx Defenders, a holistic public defender providing free legal representation, is conducting a longitudinal study examining the effects of parental involvement with the criminal justice system on this population. The study aims to understand, over time, the impact of parental CJSI on their children's mental health, including the effects of the collateral legal damage of CJSI (such as eviction and deportation), substance use, the development of risky behaviors leading to the child's potential involvement with the criminal justice system, as well as protective factors and identification of potential intervention points, which has the ability to inform public policy. 相似文献
58.
Jerod Rasmussen B. J. Casey Theo G. M. van Erp Leanne Tamm Jeffery N. Epstein Claudia Buss James M. Bjork Brooke S. G. Molina Katerina Velanova Daniel H. Mathalon Leah Somerville James M. Swanson Tim Wigal L. Eugene Arnold Steven G. Potkin MTA Neuroimaging Group 《Brain imaging and behavior》2016,10(3):761-771
Children diagnosed with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for substance abuse. Response inhibition is a hallmark of ADHD, yet the combined effects of ADHD and regular substance use on neural networks associated with response inhibition are unknown. Task-based functional Magnetic Resonance Imaging (fMRI) data from young adults with childhood ADHD with (n?=?25) and without (n?=?25) cannabis use ≥ monthly in the past year were compared with a local normative comparison group (LNCG) with (n?=?11) and without (n?=?12) cannabis use. Go/NoGo behavioral and fMRI data were evaluated for main and interaction effects of ADHD diagnosis and cannabis use. ADHD participants made significantly more commission errors on NoGo trials than controls. ADHD participants also had less frontoparietal and frontostriatal activity, independent of cannabis use. No main effects of cannabis use on response inhibition or functional brain activation were observed. An interaction of ADHD diagnosis and cannabis use was found in the right hippocampus and cerebellar vermis, with increased recruitment of these regions in cannabis-using controls during correct response inhibition. ADHD participants had impaired response inhibition combined with less fronto-parietal/striatal activity, regardless of cannabis use history. Cannabis use did not impact behavioral response inhibition. Cannabis use was associated with hippocampal and cerebellar activation, areas rich in cannabinoid receptors, in LNCG but not ADHD participants. This may reflect recruitment of compensatory circuitry in cannabis using controls but not ADHD participants. Future studies targeting hippocampal and cerebellar-dependent function in these groups may provide further insight into how this circuitry is altered by ADHD and cannabis use. 相似文献
59.
Patients suffering from connective tissue diseases (CTDs) constitute an important subgroup of immunosuppressed patients at
risk for developing serious infections. Prophylactic antibiotic administration may decrease infection-related morbidity and
mortality burden in patients with CTD, though one needs first to evaluate the overall effect of infection on morbidity and
mortality in such patients and the presence of adequate prognostic/risk factors for infection development. Studies focusing
on infection-related morbidity and mortality in patients with CTD were reviewed. Data on disease type, therapeutic regimens
used, including corticosteroid dose and method of administration as well as other immunosuppressive agents, and outcome were
extracted to evaluate the existence of specific treatment patterns predisposing to infection as well as infectious disease-related
morbidity and mortality in patients with CTD. Thirty-nine studies focusing on infection incidence and/or outcome in patients
with CTD were identified and analyzed; the majority of the reviewed studies (20) included patients with systemic lupus erythematosus
(SLE). The mortality attributed to infection was 5.2%, while the overall mortality was 20%. There were no adequate data on
the specific effect patterns of corticosteroid and immunosuppressant treatment on infection risk. Pneumocystis jiroveci (carinii) pneumonia, evaluated independently, exhibited significant mortality in patients with Wegener’s granulomatosis, polymyositis/dermatomyositis,
and SLE. In conclusion, infectious diseases are a major cause of mortality in patients with CTD. However, treatment-related
factors predisposing to serious infections have not been adequately outlined. In addition, there are no data regarding the
effect of prophylactic practices involving antibiotic administration in morbidity and mortality. 相似文献
60.
Insulin sensitivity in women with polycystic ovary syndrome 总被引:6,自引:0,他引:6
Vrbíková J Cibula D Dvoráková K Stanická S Sindelka G Hill M Fanta M Vondra K Skrha J 《The Journal of clinical endocrinology and metabolism》2004,89(6):2942-2945
The aim of our study was to compare insulin sensitivity in lean and obese European polycystic ovary syndrome (PCOS) women with lean healthy women. We performed the euglycemic hyperinsulinemic clamp in 83 women with PCOS [53 lean with body mass index (BMI) of 21.5 +/- 1.8 kg/m2 and 30 obese with BMI of 29.6 +/- 3.7 kg/m2] and in 15 healthy women with BMI of 21.6 +/- 1.8 kg/m2 to determine glucose disposal (M) and the insulin sensitivity index (ISI). Statistical evaluation was done using Kruskal-Wallis ANOVA followed by Kruskal-Wallis multiple-comparison z-value test. The basal blood glucose was significantly higher in lean and obese PCOS women than in controls (P < 0.02). Fasting insulin was significantly higher in both lean and obese PCOS women than in controls (P < 0.000001). Obese PCOS women were more insulin resistant than controls (P < 0.02 for M and P < 0.0008 for ISI); lean PCOS women did not differ from controls in M or ISI. Posthepatic insulin delivery was significantly higher in both lean and obese PCOS women compared with controls (P < 0.000008). We conclude that lean PCOS women are not more insulin resistant than healthy controls. Insulin hypersecretion, on the other hand, is present even in lean PCOS women. 相似文献